TerminatedPhase 3

Emotional Memory Reactivation in Posttraumatic Stress Disorder

Stopped: Study stopped by promoter for lack of inclusion

France5 participantsStarted 2010-09

Plain-language summary

Converging lines of evidence have implicated the amygdala in the pathophysiology of posttraumatic stress disorder. The primary purpose of our study is to assess the effect of propanolol, a beta adrenergic antagonism, on amygdala activation during a symptom provocation state in traumatized subjects with and without posttraumatic stress disorder.

Who can participate

Age range

18 Years – 50 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients of French mother language * Right-handed patients * Signature of the consent Patients: * Patients whose diagnosis of PTSD according to the criteria of the DSM IV-TR is established * PTSD whose evolution is not chronic * Established PTSD : Symptoms presents for at least 1 month * PTSD consecutive to a unique traumatic event Controls : * The healthy controls will have sudden a traumatism of the same nature or the nature comparable to that of the patients suffering from PTSD, but they will not have developed pathology * Subjects having undergone a traumatism dating less than 3 months * Examples of traumatic events: aggression, accident of the public highway, the occupational accident Exclusion Criteria: * The PTSD consecutive to several traumatic events * Patients treated by a substance crossing the blood-brain barrier (with the exception of the antidepressants of the family of the ISRS which can be indicated in the treatment of PTSD) * Histories of epilepsy or significant loss of consciousness of any origin, including post-traumatic * Any psychiatric or somatic significant pathology * The psychiatric histories in particular of suicide attempt * The pregnant or breast-feeding women * Contraindications in the propanolol * Consumption of psychoactive drugs detected in urines * Excessive alcohol consumption * The persons not being capable of understanding or of reading the information describing the study * The patients refusing to sign the for…

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Effect of propanolol, a beta adrenergic antagonism, on amygdala activation during a symptom provocation state in traumatized subjects with and without posttraumatic stress disorder

Timeframe: 34 days

Trial details

NCT IDNCT01239173

SponsorAssistance Publique - Hôpitaux de Paris

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2011-11

View on ClinicalTrials.gov More Posttraumatic Stress Disorder trials