Emotional Memory Reactivation in Posttraumatic Stress Disorder
Stopped: Study stopped by promoter for lack of inclusion
France5 participantsStarted 2010-09
Plain-language summary
Converging lines of evidence have implicated the amygdala in the pathophysiology of posttraumatic stress disorder.
The primary purpose of our study is to assess the effect of propanolol, a beta adrenergic antagonism, on amygdala activation during a symptom provocation state in traumatized subjects with and without posttraumatic stress disorder.
Who can participate
Age range18 Years – 50 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients of French mother language
* Right-handed patients
* Signature of the consent
Patients:
* Patients whose diagnosis of PTSD according to the criteria of the DSM IV-TR is established
* PTSD whose evolution is not chronic
* Established PTSD : Symptoms presents for at least 1 month
* PTSD consecutive to a unique traumatic event
Controls :
* The healthy controls will have sudden a traumatism of the same nature or the nature comparable to that of the patients suffering from PTSD, but they will not have developed pathology
* Subjects having undergone a traumatism dating less than 3 months
* Examples of traumatic events: aggression, accident of the public highway, the occupational accident
Exclusion Criteria:
* The PTSD consecutive to several traumatic events
* Patients treated by a substance crossing the blood-brain barrier (with the exception of the antidepressants of the family of the ISRS which can be indicated in the treatment of PTSD)
* Histories of epilepsy or significant loss of consciousness of any origin, including post-traumatic
* Any psychiatric or somatic significant pathology
* The psychiatric histories in particular of suicide attempt
* The pregnant or breast-feeding women
* Contraindications in the propanolol
* Consumption of psychoactive drugs detected in urines
* Excessive alcohol consumption
* The persons not being capable of understanding or of reading the information describing the study
* The patients refusing to sign the for…
What they're measuring
1
Effect of propanolol, a beta adrenergic antagonism, on amygdala activation during a symptom provocation state in traumatized subjects with and without posttraumatic stress disorder