Prospective Validation of Clini-biological Parameters Including Initial Hemostasis, Which Improve the Prediction of Death at 1 Month Among Patients With Septic Shock

Inclusion Criteria: * patient (or representative) received the information notice * patient has hemodynamic insufficiency of non-traumatic or cardiogenic origin associated with severe sepsis (treated with Noradrenalin) and organ dysfunction, hypoperfusion or hypotension * body temperature \> 38.3°C or \< 36°C * heart rate \> 90 bpm * Tachypnea \> 20 C/min or PaCO2 \< 32 mmHg or mechanical ventilation * leukocytes \> 12000 µL-1 ou \< 4000 µL-1 ou \> 10% immature forms * oliguria \< 0.5 ml/kg/h for at least 2 hours * abrupt alteration (24 h) of conscienceness * thrombocytopenia \< 100 000 G/L or disseminated intravascular coagulation * mottled skin and / or capillary refill time\> 3 sec * PaO2/FiO2 \< 300 mmHg ou \< 40KPas * Lactatemia \> 2mMol/l * septic shock: Systolic Blood Pressure (SBP) \> 90 mmHg or need for vasopressors to maintain SBP\> 90 mmHg despite a prior filling (20-30 ml / kg of macromolecules or 40 to 60 ml / kg of normal saline (or decrease in SBP\> 40% in the hypertensive) Exclusion Criteria: * patient is dying or limitation or cessation of active treatment * patient is already included in another trial * patient or family refusal * patient not affiliated with a social security system