CompletedNot Applicable

Does Valproate Increase Levels of Folate Receptor Autoantibodies in Women?

United States38 participantsStarted 2010-10

Plain-language summary

Women who take folate (folic acid) before getting pregnant can lower the risk of giving birth to infant with certain birth defects. However, some medications may affect the action of folate. The purpose of this study is to compare the effect of two anti-epileptic drugs on how folate works in our body.

Who can participate

Age range18 Years – 50 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Women ages 18-50 years inclusive who are taking valproate or lamotrigine for neurologic or psychiatric conditions * Valproate of lamotrigine must be used as monotherapy at stable doses for 6 weeks prior to the study for the neurologic or psychiatric illness; medications taken for other reasons are not excluded. Exclusion Criteria: * Women with prior exposure to valproate or lamotrigine if they are taking lamotrigine or valproate respectively.

What they're measuring

Levels of Folate Receptor Autoantibodies

Timeframe: On the same day after informed consent was obtained

Trial details

NCT IDNCT01231646

SponsorNorthwell Health

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2013-04

Results submitted2015-08-24

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