Differential Diagnosis of STA-PSV in Thyrotoxicosis (NCT01227499) | Clinical Trial Compass
CompletedNot Applicable
Differential Diagnosis of STA-PSV in Thyrotoxicosis
China169 participantsStarted 2010-06
Plain-language summary
Aim: Graves's disease and thyroiditis can both characterized with thyrotoxicosis, but their clinical outcome and therapy is quiet different. Measurement of iodine uptake is the gold standard to differential diagnosis the thyroiditis or Graves's disease. But the iodine uptake is limited for its availability in china and easily influenced by medicine or food contained iodine.The blood pattern of thyroid CFDS is useful for differentiate the cause of thyrotoxicosis.Most previous studies using the descriptive pattern of thyroid CFDS is easily varied by operator subjective judgement. This study is focus on the role of peak systolic velocity of thyroid superior artery in differential diagnosis of thyrotoxicosis. Methods: Patients with thyrotoxicosis symptoms without recent medicine history were enrolled in two clinical center. Its thyroid function, iodine uptake , CFDS of thyroid and peak systolic velocity of thyroid superior artery is detected. Thyrotoxicosis is defined as TSH level below the low value of normal range. Graves disease is defined as the typical symptoms of graves disease such as graves ophthalmopathy or increased iodine uptake. Thyroiditis is defined as lack of typical symptoms of graves disease or decreased iodine uptake.We use receiver operator curve(ROC) to evaluate its diagnosis value
Who can participate
Age range
15 Years – 85 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* newly diagnosed without taking any antithyroid drug or beta receptor blocker with TSH level below the lower limits of reference range
* is willing to be enrolled
Exclusion Criteria:
* unwilling
* taking antithyroid drug or beta receptor blocker
* taking foods or medicine rich in iodine in 8 weeks
* women with pregnant or lactation
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This study measured peak systolic velocity in the superior thyroid artery (STA-PSV) and iodine uptake to help tell apart Graves' disease from thyroiditis — could either of these tests help clarify my own diagnosis, and are they available at your clinic?
2Since this trial is completed and was focused on diagnostic accuracy rather than a new treatment, are there published results I could review with you that might explain how STA-PSV measurements compare to iodine uptake scans for distinguishing my type of thyrotoxicosis?
3If the findings from this study suggest that ultrasound blood flow measurement is a reliable way to differentiate Graves' disease from thyroiditis, would that approach change how you're planning to diagnose or treat my condition?
4Because this was a diagnostic study and not a treatment trial, what are the standard next steps for someone with my type of thyrotoxicosis, and would the distinctions this trial was measuring — between Graves' disease and thyroiditis — actually affect which treatment path you'd recommend for me?
5This study was labeled phase 'NA,' which typically means it wasn't testing a new drug but rather a diagnostic method — does that mean the main benefit of this research is helping doctors like you make more confident diagnoses, and how confident are you currently in my diagnosis without these additional tests?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.