Efficacy of Vitamin D on Top of Pegylated Interferon and Ribavirin in Patients With Chronic Viral Hepatitis C Null-Responders

Inclusion Criteria: * Chronic Hepatitis C Genotype 1 or 4 * Hypovitaminosis D defined by a value \<30 ng / ml * Patient non responder to previous antiviral combination therapy of Pegylated Interferon and Ribavirin defined by a decrease in viral load \<2 log at week 12 of the first course (Peg/RBV) * Patient who received at least 80% of the optimal dose of Pegylated Interferon and Ribavirin according to current recommendations * Patient for which the investigating physician decided to initiate treatment for hepatitis C combination therapy Exclusion Criteria: * Decompensated liver disease: Child-Pugh B\> 8 or one of the following criteria: bilirubin\> 35 micromol/L, TP \<50%, ascites, recurrent encephalopathy * Positive serology for HBV and HIV * Alcohol consumption exceeding 50 g/day * Chronic intake of vitamin D * Thrombocytopenia \<50 000/mm ³, neutropenia \<750/mm ³, hemoglobin \<11 g/dL * Pregnant women