CompletedPhase 2

Study on the Effect of a Beta Blocker on Increased Sensitivity to Pain in Humans Caused by Opioids

United States10 participantsStarted 2009-02

Plain-language summary

This research study explores whether a beta-blocker (propranolol) can prevent a person from becoming more sensitive to pain after administration of an opioid (remifentanil). Beta blockers inhibit the sympathetic (fight or flight) response and are often used to treat angina and high blood pressure. In a previous study in human volunteers, the investigators demonstrated an increased sensitivity to pain after a 60-minute infusion of the opioid remifentanil. The goal of this study is to identify a possible inhibitor of this phenomenon.

Who can participate

Age range18 Years – 45 Years

SexMALE

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Inclusion criteria

✓. Healthy men,
✓. Age between 18 and 45 years
✓. Normal weight (according to the table provided by Metropolitan Life Insurance).

Exclusion criteria

✕. Hypersensitivity to opioids or naloxone,
✕. History of addictive disease,
✕. Significant cardiac, respiratory, gastrointestinal, neurological, dermatological, and psychiatric diseases,
✕. Concurrent medication with an analgesic drug,
✕. Student and employees affiliated with our laboratory

What they're measuring

Percent Change From Baseline in Size (Area) of Secondary Hyperalgesia After Cessation of Remifentanil Infusion, a Measure of Opioid-induced Hyperalgesia (OIH).

Timeframe: Baseline; 15 min post remifentanil (REM) infusion; 60 min post REM infusion

Trial details

NCT IDNCT01222091

SponsorStanford University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2011-05

Results submitted2016-02-09

View on ClinicalTrials.gov More Hyperalgesia trials