Thymus Transplantation Safety-Efficacy

Inclusion criteria for implantation of cultured thymus tissue: * Must have 1 of following: 22q11.2ds or 10p13 hemizygosity; hypocalcemia requiring replacement; congenital heart disease; or CHARGE syndrome or CHD7 mutation * Complete DiGeorge: \<50 CD3+ T cells/cumm or \<50 CD3+ T cells/cumm that are CD62L+ CD45RA+, or \<5% of CD3+ cells are CD62L+ CD45RA+ * Atypical DiGeorge subjects must have, or have had, a rash. Group 1 •Typical cDGA whose T cells have a phytohemagglutinin (PHA) response of \< 5,000 counts per minute (cpm) and \< 20 fold PHA response. Group 2 •Typical cDGA whose T cells have a PHA response of \>5,000 cpm and \<50,000 cpm and \>20 fold PHA response. Group 3 * Typical cDGA whose T cells have a PHA response of \>50,000 cpm. * Typical cDGA with maternal engraftment * Atypical cDGA whose T cells have a PHA response of \<40,000 cpm when on immunosuppression or \<75,000 cpm to PHA when not on immunosuppression. * Atypical cDGA with group 3 PHA response \& maternal engraftment Group 4 * Atypical cDGA with PHA responses of \>75,000 cpm while on no immunosuppression or a PHA responses of \>40,000 cpm while on immunosuppression. * Atypical cDGA with maternal engraftment and group 4 PHA response Exclusion criteria for implantation of cultured thymus tissue: * Heart surgery conducted less than 4 weeks prior to projected implantation date. * Heart surgery anticipated within 3 months after the proposed time of implantation * Rejection by surgeon or anesthesiol…