The Effect of Non-surgical Periodontal Treatment in the Renal Function of Patients With Chronic Kidney Disease: RCT

Inclusion Criteria: * Chronic Kidney Disease (Stage II, III, IV) * At least 12 teeth present in the oral cavity * Moderate to severe chronic periodontitis, which is defined as: at least 8 surfaces with periodontal pocket depth (PPD) ≥5mm and at least 4 surfaces with Clinical Attachment Loss (CAL) ≥4mm, distributed in at least two quadrants. Exclusion Criteria: * Patients that have had a renal transplant or undergoing dialysis * Acute infections or use of antibiotics in the past 3 months. * Auto-immune diseases, conditions that cause immunosuppression or use of immunosuppressant medication. * Systemic conditions that require antibiotic prophylaxis for routine periodontal therapy. * Non-surgical periodontal therapy in the past 6 months or surgical periodontal therapy in the past 12 months. * Use of medication that can cause gingival hyperplasia such as cyclosporine or fenintoin. * Myocardial infarction or cerebral vascular incident in the past 12 months or uncontrolled angina.