Rapamycin In Angiomyolipomas In Patients With Tuberous Sclerosis

Inclusion Criteria: Diagnosis of tuberousclerosis Angiomyolipoma \>2cm age\>10 years Exclusion Criteria: Creatinine \>4 No recent AML bleeding No hepatic abnormalities (liver tests 2fold) Hematocrit\<27% Thrombocytopenia (\<100.000/mm3) Leukopenia (\<3000/mm3) Ischemic cardiopathy Recent surgery (2 months prior to enrollment) Pregnancy Serum cholesterol over 7.8 mmol/l or hypertriglyceridemia fasten(\>4.6 mmol/l) non controlled with drugs malignancy in the previous 2 years allergy to macrolides