Auto-immunity and Pulmonary Arterial Hypertension

Inclusion Criteria: age over 18 * for PAH patients: pre-capillary PAH evidenced by right-heart catheterization * no associated systemic disease for idiopathic PAH patients * for HIV patients, HIV1 infection confirmed by ELISA and western blot * for patients with porto pulmonary hypertension: evidence by endoscopy of esophageal varices, confirmation of hepatic venous pressure gradient over 5 mmHg by catheterization of the hepatic veins * for patients with congenital heart defect: evidence by imaging of atrial or ventricular septal defect, or patent ductus arterious and confirmed by heart catheterization * patients with SSc will fulfill the American College of Rheumatology (ACR) and the LEROY and MEDSGER criteria * patients with MCTD will fulfill the criteria for MCTD * patients with SLE will fulfill the updated and revised ACR criteria * patients with Sjögren's syndrome will fulfill the American-European consensus group criteria * patients with chronic thromboembolic pulmonary hypertension: Lung scintiscan showing segmental mismatched perfusion defects and confirmation by angiography of the occlusion and the chance of success of endarterectomy according to the location of disease * Signed written informed consent * Patients with health insurance Exclusion Criteria: * age under 18 * pregnant women * absence of written informed consent * associated malignant tumor