Effects of the Beta-blocker Nebivolol (Bystolic) on Subjects With High Normal Blood Pressure and/or a Family History of Hypertension

Inclusion Criteria: * • Prehypertensive male and female subjects with SBP =120-139 or DBP =80-89 with at least one known family member (must be diagnosed prior to the age of 60) with essential hypertension (confirmation may be sought). * All ethnicities * Non-smokers and non-drug abusers, no current smoking or illicit drug use in the prior 3 months. * Aged 18-40 years * No known serious medical conditions requiring close monitoring from physicians- such as liver impairment, chronic kidney disease, or diabetes mellitus * Subjects will need to remain in the San Diego area for the duration of the study (10 weeks) and be accessible by telephone or email. * Female subjects must be willing to use a birth control method, such as abstinence, birth control pills, diaphragm, condom, or intrauterine device to prevent pregnancy during the study. Exclusion Criteria: * Subjects with SBP \>140 or SBP\<120 or DBP \>90 and DBP\<80 * We will exclude subjects whose family members have known secondary etiologies for hypertension such as hyperaldosteronism or Cushing's Disease. * Subjects cannot have a chronic medical condition that is actively treated by a physician, such as liver impairment, diabetes, or kidney disease * History of bronchial asthma or chronic obstructive pulmonary disease * Subjects cannot be on any anti-hypertensive medications for any reason. * Subjects may not have previous intolerance, hypersensitivity, or allergy to any beta blocker therapy or may have cont…