UnknownPhase 4

Study of Administration Of Antithrombin in Patients With Low Plasmatic Levels of Antithrombin After Cardiac Surgery

Italy90 participantsStarted 2009-09

Plain-language summary

General and specific objectives of the search: evaluate the effects of the administration of Antithrombin III (ATIII) on the activation of the coagulation system and of the fibrinolysis, platelet function, inflammatory response and markers of organ damage in patients undergoing cardiac surgery by cardiopulmonary bypass (CPB) with low plasma levels of post-operative Antithrombin (AT).

Who can participate

Age range18 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * All patients were candidates for cardiac surgery intervention in extracorporeal circulation Exclusion Criteria: * positive history for allergic reactions to AT III * cardiac surgery "Off-Pump" * administration of AT during surgery or within 48 h * treatment with drugs and non-steroidal steroids within 48 h prior * disorders of coagulation * platelets \<30,000 * pre-existing IRC in dialysis treatment * severe liver failure * enlistment in another trial in the last 30 days * hypothermia * emergency * reopening * length of CEC\> 180 minutes * subjects incapable of giving legal consent

What they're measuring

Number of participants with reduced bleeding, transfusion requirements and need of reintervention for bleeding as a measure of efficacy.

Timeframe: until 5 days after surgey

Trial details

NCT IDNCT01201070

SponsorUniversity of Bari

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2011-11

Contact for this trial

Domenico Paparella, MD

+39 080 559 5075 dpaparella@cardiochir.uniba.it

View on ClinicalTrials.gov More Aortic Valve Insufficiency trials