Stopped: Not a treatment/applicable clinical trial
This research study is studying biomarkers in samples from patients with endometrial cancer. Studying samples from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
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Clinical sensitivity and specificity of epigenetic biomarkers in a cohort of blind samples (Project 2)
Timeframe: 1 month
Confirmation of CpG island loci frequently hypermethylated in EECs exhibiting recurrence (Project 2)
Timeframe: 1 month
Development of a molecular screening regimen to compliment family history risk assessment for the detection of Lynch syndrome (Project 3)
Timeframe: 1 month
Expression of candidate ERK1/2 substrates in the normal endometrium, primary endometrial cancers and endometrial cancer cell lines dependence of substrate phosphorylation on ERK (Project 4)
Timeframe: 1 month
Frequency of Lynch syndrome-related endometrial cancer and relationships between inherited and acquired DNA mismatch repair defects and clinicopathologic variables (Project 3)
Timeframe: 1 month
GSK3β inhibition as a therapeutic treatment of endometrial cancer and role of inhibiting other ERK substrates in endometrial cancer cell lines (Project 4)
Timeframe: 1 month
Identification of cognate FGF ligands and receptors expressed in normal endometrium and endometrial cancers (Project 1)
Timeframe: 1 month
Identification of profiles of CpG island hypermethylation for stratifying subtypes of EECs (Project 2)
Timeframe: 1 month
Predictive and prognostic accuracy of a panel of SNPs alone and with informative clinical, surgical, and pathologic variables in a cohort of Caucasian women with stage IB or IC vs IIIC endometrioid endometrial cancer from WUSM and GOG-0210 (Project 5)
Timeframe: 1 month
Relationship between ERK substrate phosphorylation status and upstream ERK signaling pathway activation in primary endometrial cancers and clinicopathologic significance of ERK substrate expression(Project 4)
Timeframe: 1 month
Relationship between inherited variation in the MLH1 DNA repair gene and somatic (acquired) inactivation of MLH1 in sporadic endometrial cancer (Project 3)
Timeframe: 1 month
Role of FGFR2 mutations in low, intermediate and high risk endometrial cancers (Project 1)
Timeframe: 1 month