CompletedNot Applicable

Preoperative Misoprostol in Reducing Blood Loss in Total Abdominal Hysterectomy (TAH)

Hong Kong77 participantsStarted 2007-01

Plain-language summary

Total abdominal hysterectomy is known to be associated with operative blood loss, which can lead to patients' morbidity. Misoprostol, a prostaglandin, has been shown to be effective in reducing operative blood loss during myomectomy. It is the first study to investigate if preoperative misoprostol is effective in reducing operative blood loss during total abdominal hysterectomy.

Who can participate

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * symptomatic women undergoing total abdominal hysterectomy for various benign gynaecological diseases in Queen Mary Hospital Exclusion Criteria: * any contraindication to misoprostol, including mitral stenosis, glaucoma, sickle cell anaemia, diastolic pressure over 100mmHg, severe asthma, or known allergy to prostaglandin; * a known history of pelvic/ovarian endometriosis; * a known history of or active medical disease; * a known history of previous myomectomy; * women who had pre-operative mifepristone or gonadotrophin releasing hormone analogues treatment; * women with mental impairment or incompetent in giving consent.

What they're measuring

operative blood loss

Timeframe: duration of operation, up to 3 hours

Trial details

NCT IDNCT01199159

SponsorThe University of Hong Kong

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2008-04

View on ClinicalTrials.gov More Hysterectomy trials