TerminatedNot Applicable

Inflammation and Oxidative Stress of Adipose Tissue in Sleep Apnea Syndrome

Stopped: Enrollment difficulty

France40 participantsStarted 2010-10-16

Plain-language summary

The main objective of this study is to evaluate the decrease of inflammation of adipose tissue in obese and non-obese patients having a sleep apnea syndrome and treated or not by continuous positive airway pressure (cPAP). An interim analysis will be performed when 40 patients will be included.

Who can participate

Age range18 Years – 69 Years

SexMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Male between 18 and 70 years old * Apnea Hypopnea Index \> 30/h and \> 5% TST with SaO2 \< 90% * patients obese (BMI \> 33kg/m2) or non obese (BMI \< 27kg/m2) Exclusion Criteria: * Female * coronary ischemic disease, past history of CVA * chronic pulmonary disease measured by arterial gasometry (PaO2 \< 60mmHg and/or PaCO2 \> 45mmHg) * known hepatic disease * alcohol consumption \> 3 units/day * sleepiness considered to be dangerous by the investigator * patient having an hazardous work regarding to awareness * patient being under anticoagulant, antiplatelet drug or having an active stent or bleeding disorder * patient having an inflammatory syndrome (C-reactive Protein \> 10) * any allergy to local anaesthetics * chronic muscle pain * contraindication to MRI

What they're measuring

Decrease of inflammation in adipose tissue

Timeframe: 2 months

Trial details

NCT IDNCT01196845

SponsorUniversity Hospital, Grenoble

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-02-16

View on ClinicalTrials.gov More Decrease of Inflammation of Adipose Tissue trials