CompletedNot Applicable

Exercise Training in Barth Syndrome

4 participantsStarted 2010-07

Plain-language summary

Barth syndrome (BTHS) is a genetic disease that results in heart failure, muscle weakness and exercise intolerance. Several studies in non-BTHS heart failure suggest that endurance exercise training is beneficial in improving exercise intolerance, heart function and quality of life in young men with BTHS. This study will examine the effects of Endurance (i.e. aerobic) exercise training on exercise tolerance, heart function, and quality of life in adolescents and young adults with BTHS. We hypothesize that 3 months of endurance training will improve exercise tolerance, heart function and quality of life in adolescents and young men with BTHS.

Who can participate

Age range15 Years – 30 Years

SexMALE

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Inclusion criteria

✓. Age 15-30 years
✓. Sedentary (exercises less than 2x/wk)
✓. Motivated to exercise
✓. Stable on medications for ≥ 3 months
✓. Lives in North America.
✓. Planning on attending the Barth Syndrome International Conference in July 2010.

Exclusion criteria

✕. Unstable heart disease
✕. Any concurrent disease that may contraindicate exercise testing and training.
✕. Cardiac transplantation

What they're measuring

Peak oxygen consumption

Timeframe: Enrollment and 3 months

Trial details

NCT IDNCT01194141

SponsorWashington University School of Medicine

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2013-12

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