Use of Omegaven Fish Oil Emulsion for Parenteral Nutrition Associated Liver Disease in Infants and Children

Inclusion Criteria: * direct bilirubin \> 2 mg/dl x2 consecutive * parenteral nutrition dependent, expected to continue for at least another 30 days from the first day * patient must have utilized standard therapies to prevent the progression of liver disease Exclusion Criteria: * other primary cause of liver disease not parenteral nutrition-associated * weight \<3 kg * infant or child enrolled in other clinical trial involving an investigational agent