UnknownNot Applicable

Multicenter Clinical Trial for Adult Ph-negative ALL. Non-intensive But Non-iterruptive Treatment

Russia321 participantsStarted 2008-11

Plain-language summary

1. evaluation of blast clearance in b/m after 7 days of prednisolone prephase and the efficacy of its substitution by dexamethasone if blast count is 25% and more 2. feasibility for adults of "no interruptions" protocol with 8 weeks induction and 14 weeks consolidation followed by 2-years maintenance. 3. tolerability and efficacy in adults of the prolonged L-asparaginase application (total proposed dose 560.000 IU) 4. feasibility and efficacy of autologous stem cell transplantation for T-cell ALL

Who can participate

Age range15 Years – 55 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Ph-negative precursors ALL * age 15-55 years * nontreated * Eastern Cooperative Oncology Group criterion status 0-3 Exclusion Criteria: * B-mature ALL * Ph-positivity * pretreatment * Eastern Cooperative Oncology Group criterion status 4

What they're measuring

Proportion of adult ALL patients who tolerated the non-interrupted treatment

Timeframe: 3 years

Trial details

NCT IDNCT01193933

SponsorNational Research Center for Hematology, Russia

Sponsor typeNETWORK

Study typeINTERVENTIONAL

Primary completion2016-12

View on ClinicalTrials.gov More Ph-negative Adult Acute Lymphoblastic Leukemia trials