WithdrawnPhase 1

Early Noninvasive Positive Pressure Ventilation in Children With Status Asthmaticus

Stopped: Pilot early noninvasive ventilation on all children who met the criteria was effective.

United States0Started 2009-01

Plain-language summary

Status asthmaticus is recognized as a common cause of morbidity in children in the United States. In recent years, hospitalization rates have reached an all time high. This study will evaluate the safety, tolerability and clinical benefit of adding Noninvasive Positive Pressure Ventilation (NPPV)to regular care in children with moderate to moderately severe status asthmaticus.

Who can participate

Age range1 Year – 18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * children, 1- 18 years of age, with a known history of asthma admitted to the PICU at St John's Children's Hospital with status asthmaticus * clinical asthma score (CAS) between 3 - 8 after receiving one dose of systemic steroid, 1 hour of continuous albuterol (SABA), and 3 doses of ipratropium bromide * written informed consent from the patient's parent or legal guardian Exclusion Criteria: * no previous history of asthma, * absence of airway protective reflexes, * absence of respiratory drive, * excessive oral secretions, * need for emergent intubation as determined by the attending physician, * facial or airway anomaly or injury precluding the use of tight fitting mask

What they're measuring

clinical asthma score (CAS)

Timeframe: initiation, 2 hours, 4-8 hours, 12-16 hours and 24 hours after initiation

Trial details

NCT IDNCT01188473

SponsorSouthern Illinois University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2010-01

View on ClinicalTrials.gov More Status Asthmaticus trials