The Effect of Nicotine on Arousal, Cognition and Social Cognition in Schizophrenic Patients

Inclusion Criteria: * In- or outpatients with schizophrenia stably treated (same primary medication) for at least 2 months with antipsychotic therapy (treatment with more than 1 antipsychotic drug is acceptable provided dose levels have been stable for \> 2 months). Fluctuations in dose levels of the primary antipsychotic treatment are acceptable provided the dose levels remain constant as from 2 weeks prior to dosing * A known (by the site) disease history of at least 12 months * DSM-IV criteria for Schizophrenia * Willing to be hospitalized during the treatment periods of the study * Body mass index (BMI) between 18 and 35 kg/m2, inclusive (BMI = weight/height2) * Women must be: postmenopausal (for at least 12 months), surgically sterile (have had a hysterectomy or bilateral oophorectomy, tubal ligation, or otherwise be incapable of pregnancy), abstinent (at the discretion of the investigator/per local regulations), or if sexually active, be practicing a highly effective method of birth control and must agree to continue to use the same method of contraception throughout the study * Women of childbearing potential must have a negative serum pregnancy test at screening and a negative urine pregnancy test at admission (each study period) * Smoking on average a minimum of 15 cigarettes (or equivalent) per day within 6 months prior to study drug administration (only for Cohort 1) Exclusion Criteria: * Female patients who are pregnant or breastfeeding * Clinically significant…