Carvedilol for Psychostimulant Dependence

Inclusion Criteria: * 18-45 years old * Cocaine dependence, as assessed by the substance abuse section of the Structured Clinical Interview for DSM-IV. * At least weekly self-reported cocaine use during a preceding three month period * Urine toxicology screen positive for cocaine or cocaine metabolite * Women of childbearing age must have a negative pregnancy test, agree to adequate contraception to prevent pregnancy during the study, agree to monthly pregnancy testing and not be nursing Exclusion Criteria: * Suicide attempts within the past 12 months or suicidal ideations or psychotic symptoms in the past 6 months as determined by a study physician. * Current opioid, alcohol or sedative physical dependence or amphetamine dependence. * Major cardiovascular disorder that contraindicates study participation (e.g., history of myocardial infarction, stroke, congestive heart failure, cardiac arrhythmia, significant hypertension \[i.e., \>170 SBP or \>110 DBP\] or an unstable medical condition (e.g., untreated bacterial infection) as determined by the study physician. * Asthma or chronic obstructive pulmonary disease. * History of schizophrenia, or bipolar type I disorder. * Use of medications that would be expected to have major interaction with carvedilol (e.g., rifampin, cimetidine, digoxin, diuretics). * Medical contraindication to receiving carvedilol (e.g., diabetes, severe bradycardia, bronchial asthma or other bronchospastic condition, 2nd or 3rd degree AV block, sick si…