CompletedNot Applicable

Effect of Combined Exercise, Heat, and Quercetin Supplementation on Whole Body Stress Response

United States9 participantsStarted 2009-09

Plain-language summary

The purpose of this study is to determine whether dietary quercetin supplementation effects thermotolerance and heat acclimation in human subjects exposed to exercise/heat stress. Specific Aim I. To determine if quercetin in combination with repeated bouts of thermally stressful exercise will impact intestinal barrier function. The investigators will examine urinary lactulose excretion, plasma endotoxin,plasma quercetin, inflammatory cytokines (TNF-a \& Il-6), anti-inflammatory cytokines (Il-10), and HSP70 and HSF-1 content of peripheral blood mononuclear cells. Specific Aim II. To determine whether quercetin's suppresses the ability of human subjects to acclimate to exercise/heat stress. The investigators will examine body temperatures, heart rates, physiological strain, sweat and plasma volume responses to standardized heat tolerance tests.

Who can participate

Age range18 Years – 39 Years

SexMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Healthy: 1 or less CV risk factor. Positive risk factors include: * Family history * Current cigarette smoker or quit within the previous 6 months * Hypertension (\>140/90 mmHg) or on antihypertensive medication * Impaired fasting glucose (\>110 mg/dl) * Dyslipidemia (LDL\>130 mg/dl;HDL\<40 mg/dl, total \>200 mg/dl) * Low VO2 peak: \<40ml/kg/min * Overfatness(BMI\>30 kg/m2 and/or body fat \> 25%) * Male * 18-39 years of age * Willing to follow study diet * Willing to exercise for prescribed time * Willing to tolerate hot environment * Willing to avoid external influences (ambient heat, uv exposure, external exercise) for study duration Exclusion Criteria: * History of heat illness * Current NSAID use * Known gastrointestinal disease * Illness (physician provide physical before subject begin each condition)

What they're measuring

Urinary Lactulose Excretion

Timeframe: Baseline

Plasma endotoxin

Timeframe: Baseline

Plasma Quercetin

Timeframe: Baseline

Plasma TNF-a

Timeframe: pre, post, 2hours post, 4 hours post exercise on Day 1 of exercise/heat stress

plasma Il-6

Timeframe: Pre, post, 2hours post, 4 hours post exercise, day 1 of exercise/heat stress

Plasma Il-10

Timeframe: Pre, post, 2 hours post, 4 hours post exercise on Day 1 of exercise/heat stress

HSP70 content of peripheral blood mononuclear cells

Timeframe: Pre, post, 2 hours post, 4 hours post exercise on day 1 of exercise/heat stress

HSF-1 content of peripheral blood mononuclear cells

Timeframe: Pre, post, 2 hours post, 4 hours post exercise on day 1 of exercise/heat stress

Trial details

NCT IDNCT01168739

SponsorUniversity of New Mexico

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2010-03

View on ClinicalTrials.gov More Heat Acclimation and Thermotolerance trials

Plain-language summary

Who can participate

Age range18 Years – 39 Years

SexMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Urinary Lactulose Excretion

Timeframe: Baseline

Plasma endotoxin

Timeframe: Baseline

Plasma Quercetin

Timeframe: Baseline

Plasma TNF-a

Timeframe: pre, post, 2hours post, 4 hours post exercise on Day 1 of exercise/heat stress

plasma Il-6

Timeframe: Pre, post, 2hours post, 4 hours post exercise, day 1 of exercise/heat stress

Plasma Il-10

Timeframe: Pre, post, 2 hours post, 4 hours post exercise on Day 1 of exercise/heat stress

HSP70 content of peripheral blood mononuclear cells

Timeframe: Pre, post, 2 hours post, 4 hours post exercise on day 1 of exercise/heat stress

HSF-1 content of peripheral blood mononuclear cells

Timeframe: Pre, post, 2 hours post, 4 hours post exercise on day 1 of exercise/heat stress