CompletedNot Applicable

Effect of Combined Exercise, Heat, and Quercetin Supplementation on Whole Body Stress Response

United States9 participantsStarted 2009-09

Plain-language summary

The purpose of this study is to determine whether dietary quercetin supplementation effects thermotolerance and heat acclimation in human subjects exposed to exercise/heat stress. Specific Aim I. To determine if quercetin in combination with repeated bouts of thermally stressful exercise will impact intestinal barrier function. The investigators will examine urinary lactulose excretion, plasma endotoxin,plasma quercetin, inflammatory cytokines (TNF-a \& Il-6), anti-inflammatory cytokines (Il-10), and HSP70 and HSF-1 content of peripheral blood mononuclear cells. Specific Aim II. To determine whether quercetin's suppresses the ability of human subjects to acclimate to exercise/heat stress. The investigators will examine body temperatures, heart rates, physiological strain, sweat and plasma volume responses to standardized heat tolerance tests.

Who can participate

Age range

18 Years – 39 Years

Sex

MALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Healthy: 1 or less CV risk factor. Positive risk factors include: * Family history * Current cigarette smoker or quit within the previous 6 months * Hypertension (\>140/90 mmHg) or on antihypertensive medication * Impaired fasting glucose (\>110 mg/dl) * Dyslipidemia (LDL\>130 mg/dl;HDL\<40 mg/dl, total \>200 mg/dl) * Low VO2 peak: \<40ml/kg/min * Overfatness(BMI\>30 kg/m2 and/or body fat \> 25%) * Male * 18-39 years of age * Willing to follow study diet * Willing to exercise for prescribed time * Willing to tolerate hot environment * Willing to avoid external influences (ambient heat, uv exposure, external exercise) for study duration Exclusion Criteria: * History of heat illness * Current NSAID use * Known gastrointestinal disease * Illness (physician provide physical before subject begin each condition)

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Urinary Lactulose Excretion

Timeframe: Baseline

Plasma endotoxin

Timeframe: Baseline

Plasma Quercetin

Timeframe: Baseline

Plasma TNF-a

Timeframe: pre, post, 2hours post, 4 hours post exercise on Day 1 of exercise/heat stress

plasma Il-6

Timeframe: Pre, post, 2hours post, 4 hours post exercise, day 1 of exercise/heat stress

Plasma Il-10

Timeframe: Pre, post, 2 hours post, 4 hours post exercise on Day 1 of exercise/heat stress

HSP70 content of peripheral blood mononuclear cells

Timeframe: Pre, post, 2 hours post, 4 hours post exercise on day 1 of exercise/heat stress

Trial details

NCT IDNCT01168739

SponsorUniversity of New Mexico

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2010-03

View on ClinicalTrials.gov More Heat Acclimation and Thermotolerance trials

Plain-language summary

Who can participate

Age range

18 Years – 39 Years

Sex

MALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Urinary Lactulose Excretion

Timeframe: Baseline

Plasma endotoxin

Timeframe: Baseline

Plasma Quercetin

Timeframe: Baseline

Plasma TNF-a

Timeframe: pre, post, 2hours post, 4 hours post exercise on Day 1 of exercise/heat stress

plasma Il-6

Timeframe: Pre, post, 2hours post, 4 hours post exercise, day 1 of exercise/heat stress

Plasma Il-10

Timeframe: Pre, post, 2 hours post, 4 hours post exercise on Day 1 of exercise/heat stress

HSP70 content of peripheral blood mononuclear cells

Timeframe: Pre, post, 2 hours post, 4 hours post exercise on day 1 of exercise/heat stress