Arterial Microcirculation, Macrocirculation and Thrombophilias

Inclusion Criteria: * healthy volunteers * 18-45 years old women of child bearing age * Without any hormonal contraception nor any hormone treatment since at least 3 months * Without any arterial risk factors (HTA, diabetes, dyslipemia, obesity, including smoking\> 5 cigaret ) * Patient who have signed an inform consent * With no thrombophilia : normal sample for factor V and II mutations * Willing to participate to the study * Adherent to health insurance * Previous Clinical examination * women with thrombophilia * 18-45 years old women of child bearing age * Without any hormonal contraception nor any hormone treatment since at least 3 months * Without any arterial risk factors (HTA, diabetes, dyslipemia, obesity, including smoking\> 5 cigaret ) * Patient who have signed an inform consent * With thrombophilia : normal sample for factor V and II mutations * Willing to participate to the study * Adherent to health insurance * Previous Clinical examination Exclusion Criteria: * Women under hormonal contraception or who have stopped it less than 3 months ago * Women under anticoagulant * Arterial risk factor : HTA, diabetes, dyslipemia, obesity(BMI\>30), including smoking\> 5 cigarets ), metabolic syndrome, antiphospholipids/anticoagulant antibody, SLE * History of coronaropathy or of stroke * Pregnant women or willing to conceive * Severe liver disease * Women of less than 18y or older than 45y * Severe liver diseases * Patient not willing t…