CompletedNot Applicable

Treatment of Group A Beta Hemolytic Streptococcal Pharyngitis in Children in Low Resource Settings

Brazil, Croatia, Egypt558 participantsStarted 2001-08

Plain-language summary

The purpose of this study was to compare the microbiological effects of two different treatments: a single dose of intramuscular benzathine penicillin G (IM BPG) vs. a 10-day daily dose of amoxicillin for the treatment of GABHS pharyngitis in children in low resource settings. This study was a prospective multi-center randomized active control treatment trial. The trial is a non-inferiority equivalence trial, to determine if amoxicillin treatment is at least as effective as the currently given IM BPG treatment.

Who can participate

Age range2 Years – 12 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age: 2-12 years old, * Presenting with complaint of sore throat * Parental consent given and child assent if 5 years or older Exclusion Criteria: * The parent/guardian reported oral antibiotic use in the past 3 days or injectable penicillin in past 28 days prior to screening * Had a history of rheumatic fever or rheumatic heart disease * Required hospitalization for any reason at the time of enrollment * Had previously been enrolled in the study

What they're measuring

Eradication of Group A Streptococcus (GAS)

Timeframe: 21-28 days after 1st visit

Trial details

NCT IDNCT01156740

SponsorJohns Hopkins University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2003-04

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