CompletedPhase 1/2

Input of the Use of Indometacin in Gitelman Syndrome as Compared to Potassium Sparing Diuretics

France33 participantsStarted 2010-02

Plain-language summary

Gitelman syndrome is a rare renal disease where the kidneys are unable to normally retain some salts (sodium, potassium and magnesium). Main consequences of these renal leaks of salts are a tendency toward low blood pressure, hypokalemia and hypomagnesemia both contributing to cardiac and muscles symptoms.

Who can participate

Age range18 Years – 60 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * patients 18-60 yrs old, both sex, with genetically proven Gitelman's syndrome, under birth pill control for woman. Exclusion Criteria: * counter-indication to treatment under study * Other diuretic or NAIS treatments than amiloride, spironolactone, or indometacin

What they're measuring

To evaluate the efficacy of indomethacin on hypokalemia versus potassium and magnesium supplementation alone

Timeframe: 2 months

Trial details

NCT IDNCT01146197

SponsorAssistance Publique - Hôpitaux de Paris

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2012-12

View on ClinicalTrials.gov More Gitelman Syndrome trials