Background: \- Genetic variation in a particular chromosome is a major contributor to the increased risk for kidney disease that is common in people of African descent, although the specific gene, mutations, and other aspects of the variations remain to be determined. By studying the outcomes of kidney transplant in donors and recipients of African descent, researchers hope to better understand the effects of this genetic variation on the success of kidney transplants. Objectives: \- To examine possible connections between genetic variations and kidney transplant outcomes for donors and recipients. Eligibility: * Participants in kidney transplant where both donor and recipient were of black African descent. * Eligible transplants include both living donor and deceased donor. Design: * The study will involve one visit of up to 8 hours. * All participants will provide a detailed personal and family medical history. * All participants will provide blood and urine samples, including a 24-hour urine collection, to test kidney function and collect material for genetic testing. * Donor participants will also have a magnetic resonance imaging (MRI) scan of their remaining kidney.
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Whether variation in other donor genes might contribute to donor and recipient outcomes
Timeframe: 1995-2006