WithdrawnNot Applicable

Acetaminophen in Combination With N-Acetylcysteine (NAC) Versus Placebo in Treating Fever

Stopped: Unable to recruit sufficient participants due to lack of funding; PI has left the institution.

United States0Started 2009-04

Plain-language summary

The purpose of this study is to compare the efficacy of the an N-acetyl-p-aminophenol (APAP, also known as acetaminophen) and N-acetylcysteine (NAC) combination versus an APAP-placebo combination as an anti-pyretic agent.

Who can participate

Age range18 Years – 75 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * adults aged 18 to 75 years old * admitted to an inpatient unit at Columbia-Presbyterian Medical Center * fever defined as an oral temperature of 38.5°C Exclusion Criteria: * if oral temperature cannot be obtained * abnormal aminotransferase levels * prior adverse reaction to acetaminophen or N-acetylcysteine

What they're measuring

Difference in temperature reduction between participants who are administered combination N-acetyl-p-aminophenol and N-Acetylcysteine (APAP-NAC) versus combination APAP-placebo

Timeframe: 6 hours after study drug administration

Trial details

NCT IDNCT01137591

SponsorColumbia University

Sponsor typeOTHER

Study typeINTERVENTIONAL

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