CompletedNot Applicable

A Study to Evaluate the Effect of Mechanical Ventilation on the Inferior Vena Cava Collapsibility Index

United States32 participantsStarted 2009-10

Plain-language summary

Previous research has shown that the Inferior Vena Cava Collapsibility Index (IVCCI) can be used to assess volume status. One limitation of the previous work is that changes in intra-thoracic pressure can influence this measurement, and the magnitude of this effect has never been described. The investigators aim is to correlate the degree of change in IVCCI with the set degree of change in intra-thoracic pressure in a heterogeneous population of critically ill patients.

Who can participate

Age range18 Years – 99 Years

SexALL

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Inclusion criteria

✓. Age\>17 years
✓. Current use of mechanical ventilation through an endotracheal tube.
✓. Admitted to ICU within last 48 hours

Exclusion criteria

✕. Severe COPD by history (documented FEV1\<50% predicted or CT evidence of emphysema)
✕. Current suspected Asthma Exacerbation
✕. Profound Hypoxia defined as a FiO2 requirement \>90% or a PEEP \>10 mmHg
✕. Patient-ventilator desynchrony or active agitation
✕. Unstable O2 requirement as determined by the primary clinical team.
✕. Prisoners
✕. Bedside clinician refusal (physician or treating nurse).
✕. Cardiovascular instability (any increase in rate of vasopressors or i.v. fluid bolus for hypotension within the last four hours)

What they're measuring

Determine the effect of an increase in positive end-expiratory pressure on intrathoracic pressure variables in patients with acute respiratory failure.

Timeframe: 24 months

Trial details

NCT IDNCT01136109

SponsorNaeem Ali, MD

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2013-02

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