CompletedNot Applicable

Safety of Bronchial Allergen Challenge and Predictors for Positive Reaction.

Germany425 participantsStarted 2011-01

Plain-language summary

The present study is aimed to evaluate a bronchial allergen challenge with house dust mite and alternaria. Firstly, the years 2005, 2006, 2007, 2008 and 2009 will be retrospectively reviewed. Secondly, in 2010-2013, in the prospective part of the study the patients will undergo the bronchial allergen challenge to examine safety of the bronchial allergen challenge and change of allergen specific bronchial hyperreactivity before and after allergen specific immunotherapy.

Who can participate

Age range5 Years – 18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Informed consent * Age between 5 and 18 years * Known house dust mite or alternaria allergy Exclusion Criteria: * Age \< 5 years and \> 18 years * Lung function VC \< 80 % and FEV1 \< 75 % * Others chronic diseases or infections (e.g., HIV, tuberculosis, malignancy) * Pregnancy * Treatment with systemic corticosteroids * Documented alcohol, substance, and/or drug abuse * Incapability to perform all study procedure

What they're measuring

Safety of bronchial allergen challenge with house dust mite and alternaria.

Timeframe: 10 hours

Trial details

NCT IDNCT01134757

SponsorJohann Wolfgang Goethe University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2011-12

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