RecruitingNot Applicable

Imaging Techniques in MRI

United States1,000 participantsStarted 2010-06-05

Plain-language summary

Background: \- Magnetic resonance imaging (MRI) scans must be performed according to specified sets of parameters that provide optimal images of each organ and each area of the body. These scanning parameters are often specific to the institution or organization at which they are employed, and may also depend on the manufacturer of the MRI scanning equipment. Because MRI scanning equipment is always being updated and upgraded, researchers are interested in developing new and optimized scanning parameters for MRI scans. Objectives: \- To improve current methods and develop new techniques for magnetic resonance imaging. Eligibility: * Individuals 18 years of age and older who are either volunteers or current NIH protocol participants. * Participants must not have any medical history factors (e.g., extreme claustrophobia, history of metal implants) that would prevent them from receiving MRI scans. Design: * Participants will have at least one MRI scan that will last from 20 minutes to 2 hours (most scans will last between 45 and 90 minutes). The total time commitment for most visits will be approximately 4 hours from start to finish. * Some MRI techniques require standard monitoring equipment or specific procedures during the scanning, such as an electrocardiogram. * Participants will have blood samples taken at the time of the scan. Some MRI studies will require the use of a contrast agent that will be administered during the scan. * Volunteers may be asked to return for additional MRI scans over the course of a few years. Follow-up scans may be done on the same part of the body or on different parts of the body. No more than one MRI scan will be performed in any 4-week period for this protocol....

Who can participate

Age range

18 Years – 100 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

* INCLUSION CRITERIA: A. Volunteer individuals B. Lab Eligibility parameters (for contrast scans within 4 weeks of gadolinium injection): C. Creatinine below upper normal limit D. eGFR \>= 60 mL/min/1.73m2 E. Age \>= 60 or history of renal disease: test GFR within 1 week prior to contrast F. Willing to travel to the NIH for follow-up visits. G. 18 years old H. Able to understand and sign informed consent I. No MRI scan with gadolinium injection in the last 6 months under this protocol. EXCLUSION CRITERIA: A. Implanted metal clips or wires of the type which may concentrate radiofrequency fields or cause tissue damages from twisting in a Magnetic field. Examples: * Aneurysm clip, implanted neural stimulator, * Implanted cardiac pacemaker, defibrillator, or certain other implanted electrical or metallic devices, * Cochlear implant, ocular foreign body (metal shavings), * Any implanted device (pumps, infusion devices, etc.), * Shrapnel injuries, * History of metal in head or eyes or other parts of the body. B. Pregnant women C. Paralyzed hemidiaphragm D. Over 500 lbs and/or a body circumference that prevents the study subject from laying flat in the scanner E. Surgery of uncertain type F. Untreatable claustrophobia otherwise requiring anesthesia. G. Any contraindications that the Physician identifies from the subject, MRI Safety Questionnaire, and/or History and Physical. EXCLUSION FOR PARTICIPANTS FOR GADOLINIUM CONTRAST: (Inclusive of the above exclusion cri…

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

To refine current methodology and develop new techniques for MRI

Timeframe: End of study

Trial details

NCT IDNCT01130545

SponsorNational Institutes of Health Clinical Center (CC)

Sponsor typeNIH

Study typeOBSERVATIONAL

Contact for this trial

Tracy L Cropper, R.N.

(301) 402-6132 tcropper@cc.nih.gov

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