Safety, Tolerability, Pharmacodynamic and Pharmacokinetics of a Single Rectal Application of 10 mg NRL001 in Elderly Subjects

Inclusion Criteria: Volunteers will be included in the study if they satisfy the following criteria: * Healthy adult male or female volunteers (as determined by medical history, physical examination, laboratory test values, vital signs and electrocardiograms \[ECGs\] at screening) aged ≥65 years. * Non-smokers from 3 months before receiving the first dose and for the duration of the study. * Body mass index (BMI) ≥ 18 and ≤ 32 kg/m2. * Able and willing to receive rectal treatments. * Able to voluntarily provide written informed consent to participate in the study. * Sexually active male volunteers must use condoms with their partners throughout the study and for 90 days after completion of the study in addition to their partner's normal mode of contraception. * Male volunteers must not donate sperm during the study and for 90 days after completion of the study. * Must understand the purposes and risks of the study and agree to follow the restrictions and schedule of procedures as defined in the protocol. * Female volunteers must be postmenopausal (for at least 1 year, confirmed by FSH testing at screening). * Must be willing to consent to have data entered into The Over Volunteering Prevention System (TOPS). * The volunteer's primary care physician must confirm that there is nothing in their medical history that would preclude their enrolment into this clinical study. Exclusion Criteria: Volunteers will be excluded if they fulfil any of the following criteria: * Positive…