GAME Veterans With PTSD Using Computer-Based Cognitive Training (NCT01087775) | Clinical Trial Compass
CompletedNot Applicable
GAME Veterans With PTSD Using Computer-Based Cognitive Training
United States25 participantsStarted 2010-04
Plain-language summary
The investigators hypothesis are as follows:
H1a: OEF/OIF veterans with PTSD who perform cognitive training (CT) will demonstrate greater objective improvements on standard (untrained) neurocognitive measures, with the largest gains in verbal memory, learning and sustained attention.
H1b: Objective cognitive improvements in CT participants will be sustained at three months post-intervention, suggesting persistence of neuroplasticity-based cognitive training benefits.
H2a: OEF/OIF veterans with PTSD who perform CT will report greater improvements in cognitive function.
H2b: OEF/OIF veterans with PTSD who perform CT will demonstrate improved social and occupational functioning and quality of life.
H2c: OEF/OIF veterans with PTSD who perform CT will demonstrate greater improvements in community reintegration.
Who can participate
Age range18 Years – 40 Years
SexMALE
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Confirmed OEF and/or OIF military service
✓. Male veterans, ages 18 to 40 years with 12 to 16 years of education
✓. History of a prior positive PTSD screen or diagnosis either by SFVAMC study referral or self-report'
✓. Able and willing to travel to SFVAMC
✓. Able and willing to perform daily home-based computer exercises for three months.
✓. The Clinician-Administered PTSD screen (CAPS) and the Mini International Neuropsychiatric Interview (MINI) 29 to assess for Diagnostic and Statistical Manual (DSM)-IV Axis I psychiatric disorders
✓. The VA TBI second-level screen \[TBI event history and Neurobehavioral Symptom Inventory (NSI) for cognitive symptoms\].30
✓. Meet threshold criteria for current full or sub-syndromal PTSD by DSM-IV criteria 31
Exclusion criteria
✕. Poor English comprehension and fluency
What they're measuring
1
Change Scores of Standard (Untrained) Neurocognitive Measures (Verbal Memory, Learning and Sustained Attention)
✕. Unstable medical condition, injury or disability, including moderate to severe TBI (by self-report) and hearing impairment
✕. Current (or past 60 day) evidence-based PTSD or cognitive remediation therapy; in contrast, stable supportive therapy for PTSD and/or other mental disorders, such as group therapy or on stable psychoactive medication (\> 30 days) will be acceptable.
✕. Drug and alcohol dependence and other unstable serious mental illness (e.g. psychosis) (assessed using the MINI)