Repair of Challenging Abdominal Wall Defects: Strattice(TM) TM in Abdominal Wall Repair (StAR)

Inclusion Criteria: * adults (18years of age or older) who is able to provide written informed consent for study participation * has need of surgical intervention for repair of (potentially) contaminated abdominal wall defect of \>3cm and \<22cm in length, where the viscera have not been exposed for more than 15 days in case of open abdomen(skin and fascia open). * Is willing and able to return for all scheduled \& required study visit. Exclusion Criteria: at the time of randomization * severe systemic sepsis * frank pus in the wound, a fistula that will not be closed at the time of surgery or intra-abdominal abscess in surgical area, * ongoing necrotizing pancreatitis, * Is on chronic immunosuppressive therapy, or other medication that influences wound healing * requires only short-term temporary closure, * requires a synthetic, non-absorbable mesh to close the abdominal wall defect * is unable to undergo general anesthesia, * has other major organ system dysfunction or disorder that would jeopardize subject completing the 24 month study. * Is unable to undergo an MRI scan