CompletedPhase 3

Smoking-Cessation and Stimulant Treatment (S-CAST)

United States538 participantsStarted 2010-02

Plain-language summary

The primary objective of this study is to evaluate the impact of substance-abuse treatment as usual plus smoking-cessation treatment (TAU+SCT), relative to substance-abuse treatment as usual (TAU), on drug-abuse outcomes. Specifically, this study will evaluate whether concurrent smoking-cessation treatment improves, worsens, or has no effect on stimulant-use outcomes in smokers who are in outpatient substance-abuse treatment for cocaine or methamphetamine dependence.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Clinical diagnosis of cocaine/methamphetamine dependence * Smoked cigarettes for at least 3 months * Currently smoking \> 6 cigarettes/day * Have an interest in quitting smoking * Enrolled in outpatient treatment at a participating site Exclusion Criteria: * Clinical diagnosis of current alcohol or sedative dependence, bipolar disorder; or a life-time diagnosis of anorexia nervosa or bulimia * Seeking/receiving treatment for opiate-agonist replacement therapy * Medical conditions that could compromise participant safety * Taking medications with known/potential interactions with bupropion * Hypersensitivity to bupropion, nicotine, or menthol * Pregnant or breastfeeding * Abnormal ECG * Recent smoking cessation treatment * Use of tobacco products other than cigarettes in the past week * Likely to enter residential/inpatient treatment within 10 weeks * Have all stimulant-positive urine drug screens during screening/baseline

What they're measuring

Stimulant-free Weeks Assessed by Self-report and Twice-weekly Urine Drug Screens

Timeframe: Week 16

Trial details

NCT IDNCT01077024

SponsorUniversity of Cincinnati

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2012-08

Results submitted2014-04-24