CompletedNot Applicable

Incidence of Vivax Along the Thai Burma Border

Thailand403 participantsStarted 2010-02

Plain-language summary

This is a continuous cohort study consisting of 200 participants (one third 6 months old to 5 years, one third 6 to 15 years old, one third ≥ 15 years old) i.e. a new patient will be recruited (from the same age group) for any patient who develops a Pv infection so that the cohort will always have 200 patients for 3 years. Each patient will be actively followed-up every 8 weeks until Plasmodium vivax infection occurs but the duration of follow up and the number of follow up visits for each patient will vary depending on when or if a vivax infection occurs and when the patient is recruited. Therefore, the minimum follow up period for each patient will be 6 months or time to vivax infection and the maximum will be 3 years if a patient does not get vivax infection and is recruited at the beginning of the study.

Who can participate

Age range6 Months

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Asymptomatic adults and children ≥ 6 months * Documented P.vivax infection in the last 12 months who have not received radical treatment with primaquine * Weight≥ 7 kg for children * Participant (or parent/guardian if \<18 years old) is willing and able to give written informed consent * Ability (in the investigators opinion) and willingness of patient or parent/guardian to comply with all study requirements Exclusion Criteria: * History of allergy to primaquine * Medical conditions such as known chronic diseases (TB, HIV, cardio vascular diseases), allergies, mental illnesses and similar conditions that could make the interpretation of symptoms or the follow up difficult. * Other conditions such as drug addiction, known poor compliance with treatment or follow up. * Inability to tolerate oral medication * Pregnancy * G6PD deficiency * Blood transfusion in the last 3 months * Microscopic evidence of Plasmodium vivax, P.falciparum, P. malariae or ovale * Fever ≥37.5C

What they're measuring

Incidence

Timeframe: Up to 3 years

Trial details

NCT IDNCT01076868

SponsorUniversity of Oxford

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2014-09-02