CompletedNot Applicable

Host Genetic Susceptibility to Avian Influenza A/H5N1

Vietnam500 participantsStarted 2008-07

Plain-language summary

The identification and characterization of susceptibility loci for H5N1 infection in humans could have profound implications. The detection of host genetic factors may shed light on key pathogenic interactions between H5N1 and human cells, assisting in identifying the viral characteristics determining pandemic potential. In addition, the identification and verification of susceptibility loci would be followed by functional studies which might point the way to new therapeutic and preventive options. The objective of this study is to investigate if host genetic factors are associated with susceptibility to influenza H5N1 illness

Who can participate

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * The individual had a clinically compatible illness (defined as respiratory symptoms and an abnormal chest x-ray or encephalitis), AND * Influenza A/H5 RNA identified in a clinical sample by reverse transcription-polymerase chain reaction \[RT-PCR\], OR * Influenza A/H5 cultured from a clinical sample, OR * High titres (1:80 or higher) of anti-H5 antibodies by microneutralization in convalescent samples of patients who had a compatible illness but no or negative RT-PCR, AND * The patient survived or if they died an archived biological specimen is available for potential DNA extraction, AND * Valid, written consent is obtained. * The biological parents and biological siblings of all the cases and any other family members linking two cases, AND * Valid, written consent is obtained.

Trial details

NCT IDNCT01074736

SponsorSouth East Asia Infectious Disease Clinical Research Network

Sponsor typeNETWORK

Study typeOBSERVATIONAL

Primary completion2010-08

View on ClinicalTrials.gov More Influenza A Virus/H5N1 Subtype trials