There are two types of external radiation treatments (proton beam and photon beam). As part of the participant's treatment, they will receive radiation to the entire central nervous system (CNS); this is known as craniospinal irradiation (CSI). In the past, photon radiation therapy has been used for CSI. In this study we will be examining the effects of proton beam radiation therapy. Studies have suggested that this kind of radiation can cause less damage to normal tissue than photon radiation therapy. The physical characteristics of proton beam radiation let the doctor safely deliver the amount of radiation delivered to the tumor that is normally delivered through standard therapy but spare more normal tissue in the process.
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Cumulative Incidence of Ototoxicity
Timeframe: 3- and 5- years post radiation treatment
Endocrine Dysfunction
Timeframe: 3- and 5- years post radiation treatment
Neurocognitive Effects
Timeframe: Baseline and Follow-up (median of 6 years)