CompletedNot Applicable

Study of a Screening Blood Test to Determine Patients' Potential Risk of Adenomatous or Advanced Colon Polyps (ACPs)

United States72 participantsStarted 2010-01

Plain-language summary

The aim of this study is to develop a blood test to determine which patients are at risk for pre-cancerous colon polyps (ACPs: Advanced Colon Polyps). The telomere length of peripheral blood lymphocytes (PBLs) can be measured from a blood sample. Mechanistic pathways and the investigator's preliminary data support PBL telomere length as a biomarker for ACPs. The long-term goal of this project is to decrease deaths from colon cancer by using a blood test to target colonoscopy for those patients who are at high risk for pre-cancerous polyps.

Who can participate

Age range50 Years – 60 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Advanced Colon Polyp Group (ACP): * Must be 50 to 60 years of age with an advanced colon polyp (ACP: advanced colon polyps are those larger than 10 mm, or a colon polyp with high grade dysplasia, or a colon polyp with villous features. Control Group (Controls): * Must be 50 to 60 years of age and have had a negative screening colonoscopy. * Controls will also have no history of adenomatous colorectal neoplasia. Exclusion Criteria: * Subjects under 50 years of age * Subjects over 60 years of age * Subjects with colon polyps less than 10 mm in size

What they're measuring

Telomere length are shorter in individuals with colon polyps.

Timeframe: 2 years

Trial details

NCT IDNCT01062035

SponsorMayo Clinic

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2013-09

View on ClinicalTrials.gov More Colonic Polyp trials