CompletedNot Applicable

Pilot Study Assessing Oxidative Stress in Children

United States102 participantsStarted 2010-02

Plain-language summary

Role fo oxidative stress in adrenal insufficiency has not been studied. The degree of oxidative stress and it's role in pediatric critical illness is unknown. Potential for significant alterations to many of thew body's regulatory pathways may result from severe oxidative stress. Further is needed to delineate what if any role oxidative stress may play

Who can participate

Age range1 Day – 18 Years

SexALL

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Inclusion criteria

✓. All patients, birth-18 years, admitted to the pediatric intensive care unit that require blood to be drawn as part of medical management consistent with "standard of care".
✓. Admission to the PICU within the last 24 hours.
✓. Subjects' legal guardian shall possess the ability to understand the purposes and risks of the study and provide an informed consent signature.

Exclusion criteria

✕. Have received steroids within the last 30 days.
✕. Pre-existing/known neuroendocrine disorder, including but not limited to disorders of the hypothalamus, pituitary, adrenal, pancreas, or thyroid gland.
✕. Have been treated at anytime with antipsychotic medication.
✕. Human immunodeficiency virus (HIV) positive.
✕. Patients who have received etomidate.
✕. Patients weighing less than or equal to 6 kilograms.
✕. Developmentally delayed.
✕. Medical urgency preventing timely administration of the consenting process, or any condition that, in the opinion of the attending physician, would place the patient at undue risk by participating.

What they're measuring

Pediatric Logistic Organ Dysfunction Score in Critically Ill Children

Timeframe: 1 years

Trial details

NCT IDNCT01052207

SponsorEmory University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2011-06

Results submitted2013-12-09

View on ClinicalTrials.gov More Adrenal Insufficiency trials