CompletedNot Applicable

Neurally Adjusted Ventilatory Assist and Synchrony in Patients With Chronic Obstructive Pulmonary Disease (COPD)

France16 participantsStarted 2009-12

Plain-language summary

NAVA used the electrical activity of the diaphragm (EAdi) to initiate and deliver in proportion of an inspiratory assistance. During inspiration, EAdi signal occurred earlier than airflow or pressure variations in the airway. The investigators hypothesized that NAVA improved patient-ventilator synchrony and reduced inspiratory workload as compared with pressure support ventilation delivered at two different cycling criteria (25 and 50 %).

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * History of chronic obstructive pulmonary disease * Admitted for acute respiratory failure requiring invasive mechanical ventilation * Currently receiving pressure support ventilation Exclusion Criteria: * Age \< 18 years * Respiratory rate \> 35 bpm * Severe hypoxemia with SpO2 \< 88 % and FIO2 \> 50 % * Heart rate \> 120 bpm * Systolic arterial pressure \< 90 mmHg * Contraindication to naso-gastric tube's insertion

What they're measuring

Inspiratory muscle workload as reflected by the diaphragmatic Pressure Time Product (PTPdi)

Timeframe: 5 minutes

Trial details

NCT IDNCT01042080

SponsorHôpital Européen Marseille

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2011-04

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