Symptomatic Therapy of Uncomplicated Lower Urinary Tract Infections in the Ambulatory Setting.

Inclusion Criteria: * Female * Age between 18 and 70 years * Written informed consent * At least one typical symptom of acute, lower urinary tract infection out of dysuria, frequency, macrohaematuria, cloudy or smelly urine or self-diagnosed cystitis * A urine dipstick test should be indicative of UTI by positive nitrite or leucocyturia Exclusion Criteria * Duration of UTI symptoms for more than 7 days before physician's visit * Clinical signs of invasiveness such as fever (axillary body temperature \>38 degrees Celsius), costovertebral pain or tenderness, rigors, nausea or vomiting * Known or suspicion of anatomical or functional abnormality of the urinary tract * Vaginal symptoms: discharge, irritation * Diabetes mellitus * Immunosuppression (e.g. prednisone equivalent \>10mg per day for \>14 days, chemotherapy, radiotherapy, immunomodulators, HIV infection, neutropenia) * Any other serious comorbidity as judged by the treating physician * Bladder catheter in situ or during the past 30 days * Pregnancy * Recurrent urinary tract infection (more than 3 infections during the last 12 months) * Antibiotic treatment during the last 4 weeks * Hypersensitivity to one of the study medications * Psychiatric illness or dementia * Unable to communicate in German or French language * Documented coagulopathy (including therapy with coumarine derivatives) or documented history of gastric or duodenal ulcer disease * Documented renal insufficiency grade III or higher (calculated GFR \<60…