Ranibizumab for the Treatment of Choroidal Neovascularisation (CNV) Secondary to Pathological Myopia (PM): an Individualized Regimen

Inclusion Criteria: * Male or female outpatients of any race, aged 18 years or older * Diagnosis of active primary or recurrent subfoveal or juxtafoveal CNV secondary to PM * Diagnosis of high myopia of at least -6 dioptres in the study eye spherical equivalent. For subjects who have undergone prior refractive or cataract surgery in the study eye, the preoperative refractive error in the study eye must have been at least -6 dioptres * Patients who have a BCVA score between 78 and 24 letters in the study eye using Early Treatment Diabetic Retinopathy Study (ETDRS)-like grading charts (approximately 6/9 - 6/96 Snellen equivalent) * Patients must give fully informed consent and be willing and able to comply with all study procedures Exclusion Criteria: * History of any surgical intervention in the study eye within two months preceding screening * Previous macular laser photocoagulation, treatment with intravitreal steroids, verteporfin with photodynamic therapy (Visudyne®) or anti-VEGF agents ranibizumab, bevacizumab or pegaptanib sodium (Macugen®) in the study eye * Previous treatment with intravenously administered bevacizumab (Avastin®) * Prior treatment in the study eye with external-beam radiation therapy, vitrectomy, or transpupillary thermotherapy * History of hypersensitivity to any of the study drugs or to drugs of similar chemical classes * History of allergic reaction to fluorescein * Concurrent use of systemic anti-VEGF agents Other protocol-defined inclusion/exc…