Combination Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed Hodgkin Lymphoma

Inclusion Criteria: * Pathologically confirmed newly diagnosed Hodgkin lymphoma (HL) meeting one of the following criteria: * Classical disease * Nodular lymphocyte-predominant disease * Stage III or IV disease with B symptoms, as defined by ≥ 1 of the following: * Unexplained weight loss \> 10% within the past 6 months * Unexplained recurrent fever \> 38°C within the past month * Recurrent drenching night sweats within the past month * Creatinine clearance or radioisotope GFR ≥ 70 mL/min OR maximum serum creatinine based on age/gender as follows: * 0.4 mg/dL (1 to 5 months) * 0.5 mg/dL (6 to 11 months) * 0.6 mg/dL (12 to 23 months) * 0.8 mg/dL (2 to 5 years) * 1 mg/dL (6 to 9 years) * 1.2 mg/dL (10 to 12 years) * 1.5 mg/dL (males) or 1.4 mg/dL (females) (13 to 15 years) * 1.7 mg/dL (males) or 1.4 mg/dL (females) (≥ 16 years) * Total bilirubin ≤ 1.5 times upper limit of normal (ULN) for age * AST or ALT \< 2.5 times ULN for age * Shortening fraction ≥ 27% by ECHO OR ejection fraction ≥ 50% by MUGA (unless due to large mediastinal mass from HL) * FEV\_1/FVC \> 60% by pulmonary function tests (PFT) (unless due to large mediastinal mass fromHL) * For children who are unable to cooperate for PFTs, the criteria are: * No evidence of dyspnea at rest * No exercise intolerance * Pulse oximetry \> 92% on room air * Not pregnant or nursing * Negative pregnancy test * Fertile patients must use effective contraception * No pathologic prolonga…