Specificity of Elevated Plasma EM66 Levels in Pheochromocytoma

Patients with pheochromocytoma/paraganglioma Inclusion criteria : * men \& women, age \> 18 years old * Newly diagnosed patient : suspicion of pheochromocytoma or paraganglioma with elevation of urinary metanephrines and/or normetanephrines along with evidence of tumor which surgical removal is considered (histological findings following surgery will be the gold standard for final diagnosis and inclusion in the study) * During follow-up of a patient with known genetic predisposition to pheochromocytoma/paraganglioma : suspicion of pheochromocytoma or paraganglioma with or without elevation of urinary metanephrines and/or normetanephrines along with evidence of a tumor which surgical removal is considered (histological findings following surgery will be the gold standard for final diagnosis and inclusion in the study) , * Patients with known pheochromocytoma/paraganglioma, whether malignant or not, whether with metanephrine secretion or not, With tumor sites at inclusion in the study * Patients informed and willing to participate in the study * Patients with medical insurance (French social security) Non inclusion criteria * Patients newly diagnosed, recently operated and the histological findings disprove pheochromocytoma or paraganglioma. * patient imprisoned or under legal protection. Patients with essential hypertension Inclusion criteria * men \& women, age \> 18 years old * paired with a patient with pheochromocytoma/paraganglioma for : gender, age (± 5 years) and ce…