Efficacy and Safety of Budesonide Foam for Participants With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis

Inclusion Criteria: * Voluntarily sign written informed consent. * Male or non-pregnant and non-lactating females. * Confirmed diagnosis (by endoscopy procedure) of active, mild to moderate UP or UPS, with disease extending at least 5 centimeters (cm) but no further than 40 cm from the anal verge. * Must possess a baseline Modified Mayo Disease Activity Index (MMDAI) score between 5 and 10. Exclusion Criteria: * History or current diagnosis of Crohn's disease and indeterminate colitis. * Prior gastrointestinal surgery except appendectomy and hernia. * Concomitant active gastrointestinal disease or distortion of intestinal anatomy. * History of diverticulitis, collagenous colitis, celiac disease, recurrent pancreatic or known gallbladder disease. * Uncontrolled, previously diagnosed type 1 or 2 diabetes mellitus. * Uncontrolled abnormal thyroid function. * Unstable significant cardiovascular, endocrine, neurologic or pulmonary disease. * Hemoglobin levels less than (\<) 7.5 grams /deciliter (g/dL). * History of sclerosing cholangitis, cirrhosis, or hepatic impairment. * Renal disease manifested by greater than (\>) 2.0 milligrams/deciliter (mg/dL) serum creatinine. * History of avascular hip necrosis, active tuberculosis, ocular herpes simplex or ocular varicella zoster, malignant disease, and human immunodeficiency virus (HIV) or hepatitis B or C. * Adrenal insufficiency. * Active systemic or cutaneous infection or toxic megacolon, fistula, perforation or abscess. * Histor…