CompletedPhase 1

Pharmacokinetics and Safety of Panobinostat in Patients With Advanced Solid Tumors and Various Degrees of Hepatic Function

United States, Netherlands, Sweden25 participantsStarted 2010-03

Plain-language summary

Panobinostat (LBH589) is a deacetylase inhibitor (DACi) which belongs to a structurally novel cinnamic hydroxamic acid class of compounds. It is one of the most potent class I/II pan-DAC inhibitor (pan-DACi) that has shown anti-tumor activity in pre-clinical models and patients with solid tumors and hematological malignancies. To date, the pharmacokinetics (PK) of panobinostat has been characterized in patients with solid tumors and hematological malignancies participating in several phase I/II clinical studies. Panobinostat PK does not appear to be different in patients with solid tumors and hematological malignancies. However, the effect of organ dysfunction on PK of panobinostat is yet to be elucidated. Kidney and liver are involved in the elimination and metabolism of panobinostat. The current study is designed to evaluate the impact of hepatic function status on panobinostat PK.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Patient has documented diagnosis of advanced solid tumor for which no standard systemic therapy exists
✓. Patient has normal or abnormal hepatic organ function
✓. Patient has provided written informed consent prior to any screening procedures

Exclusion criteria

✕. Patient needing valproic acid for any medical condition during the study or within 5 days prior to the first panobinostat dose
✕. Patient received prior treatment with DAC inhibitors including panobinostat
✕. Patient requires treatment with warfarin that cannot be switched to another anticoagulant treatment prior to starting study drug
✕. Patient has encephalopathy
✕. Patient has ascites requiring intervention
✕. Female patient who is pregnant or breast feeding or with childbearing potential and not willing to use a double method of contraception up to 3 months after the end of study treatment. Male patient who is not willing to use a barrier method of contraception up to 3 months after the end of study treatment.

What they're measuring

To assess the effect of various degrees of impairment in hepatic function as measured by the National Cancer Institute-Cancer Therapy Evaluation Program (NCI-CTEP) criteria, on the pharmacokinetics of panobinostat.

Timeframe: first 7 days

Trial details

NCT IDNCT01007968

SponsorNovartis Pharmaceuticals

Sponsor typeINDUSTRY

Study typeINTERVENTIONAL

Primary completion2012-11

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