Phase IIa Study of MP4OX in Traumatic Hemorrhagic Shock Patients

Inclusion Criteria: * Adult male or female (surgically sterile or post-menopausal or confirmed not to be pregnant) * Trauma injury (blunt and/or penetrating) resulting in lactic acidosis due to hemorrhagic shock (blood lactate level ≥ 5 mmol/L; equivalent to ≥ 45 mg/dL) * Informed consent obtained before any study-related activities Exclusion Criteria: * Not expected to survive 24 hours after randomization * Evidence of severe traumatic brain injury as defined by any one of the following: Known non-survivable head injury or open brain injury; Glasgow Coma Score (GCS) = 3, 4 or 5, or known AIS = 5 if GCS \> 5; Immediate open intracranial operation; Abnormal physical exam indicative of severe CNS or spinal injury * Significant ongoing uncontrolled hemorrhage where control of bleeding is not expected within 2 hours of randomization * Cardiac arrest prior to dosing * Estimated time from injury to dosing \> 4 hours * Estimated time from hospital admission to randomization \> 2 hours * Known or suspected pregnancy (confirmed by urine test) * Previous participation in this study * Professional or ancillary personnel involved with this study * Receipt of any investigational drug(s) within 30 days prior to study