Optimum Immunosuppression in Renal Transplant Recipients.New Onset Diabetes After Transplantation

Inclusion Criteria: * Primary renal transplant recipients with end stage renal disease * No prior history of diabetes mellitus before transplant * Absence of Immunologic risk defined by the investigator criterion and Panel Reactive Antibody (PRA) \< 50% * Absence of severe infection and hepatitis C or B infection * Efficient contraception in women during the study Additionally must meet one of these "Metabolic Criteria * Recipient age \>or =60 or * Recipient age between 45 and 59 years and at least one of the following metabolic criteria: Prior to transplantation Triglycerides (TGS) \>200mg/dl or the combination of a body mass index (BMI)\> 27 and Triglycerides\>150 mg/dl or the combination of HDL-cholesterol\<40 mg/dl for men or \<50 mg/dl for women and Triglycerides \>150 mg/dl. Exclusion Criteria: * Patients with type I or II diabetes prior to transplantation defined by the American Diabetes Association (ADA) criteria * Recipient age under 45 * Patients receiving a second renal transplant * Patients with high immunological risk or PRA (panel reactive antibody level) \>or =50% * Severe infection or hepatitis C or B infection. * Dual renal transplant or double transplant with any other organ.