Efficacy and Safety of Curcumin Formulation in Alzheimer's Disease

Inclusion Criteria: * Male or Female age ≥ 50. * Diagnosed with probable AD using NINDS-ADRDA research criteria. MMSE score ≥5 and ≤20. * No history of significant psychiatric or non-AD neurological disease. * An available caregiver to monitor and administer medication and to accompany the subject to every clinical visit. * On stable doses of concomitant medications for at least one month prior to starting study medication. Exclusion Criteria: * Current or recent major psychiatric illness that meets DSM-IV criteria (i.e. bipolar disorder, schizophrenia). * Significant uncontrolled systemic illness (i.e. chronic renal failure, chronic liver disease, poorly controlled diabetes, or poorly controlled congestive heart failure). * Recent history of gastrointestinal bleeding or ulceration. * Alcoholism or substance abuse within the past year per DSM-IV criteria. * Familial, autosomal dominant Alzheimer's disease due to a mutation in a known gene (Presenilin-1, Presenilin-2, or Amyloid Precursor Protein).