CompletedNot Applicable

Lifestyle Intervention in Obese Non-diabetic Adults With a Family History of Diabetes.

United Kingdom66 participantsStarted 2010-09

Plain-language summary

The aim of this study is to investigate weather gradual weight loss achieved with healthy lifestyle changes influence hormonal factors affecting appetite and blood glucose control in obese people without presence of diabetes.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. BMI between 30-39.9kg/m2
✓. Family history of diabetes (self reported)
✓. Normal and impaired glucose tolerance
✓. Obtain informed consent

Exclusion criteria

✕. BMI less than 30kg/m2 or more than 39.9kg/m2
✕. Presence of diabetes or any other chronic disease or disability that might interfere with the study results
✕. Anti-obesity or any other prescription medications that may interfere with the study results
✕. Pregnancy
✕. Unable to converse competently in English as special arrangements would need to be made for such people and this would be impractical in a group setting
✕. Attending another weight management programme
✕. Patients who would be unable to attend at least 75% of the programme sessions for medical or other reasons
✕. Unable to provide informed consent.

What they're measuring

To estimate the correlation between weight loss over 8 months achieved through a programme of intensive lifestyle management and changes in GLP-1 production over the same period in obese without presence of diabetes but with family history of diabetes.

Timeframe: 8 month lifestyle programme

Trial details

NCT IDNCT00993603

SponsorThe Royal Bournemouth Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2012-10

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